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Detection of a Sexually Transmitted Hepatitis C Virus Protease Inhibitor-Resistance Variant in a Human Immunodeficiency Virus–Infected Homosexual Man

25/07/2014

Sandra Franco, et al. Detection of a Sexually Transmitted Hepatitis C Virus Protease Inhibitor-Resistance Variant in a Human Immunodeficiency Virus–Infected Homosexual Man. Gastroenterology. 2014 May 21. pii: S0016-5085(14)00658-1

Abstract

There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus–infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs.

 

Read abstract online in Gastroenterology

Sandra Franco, Cristina Tural, Maria Nevot, José Moltó, Jürgen Kurt Rockstroh, Bonaventura Clotet, Miguel Angel Martinez

 

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Grups d’IrsiCaixa vinculats: Variabilitat genètica i fenotípica del VIH i del VHC