CONTENIDO

  • Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity

    Pauls, Eduardo; Badia, Roger; Torres-Torronteras, Javier; Ruiz, Alba; Permanyer, Marc; Riveira-Muñoz, Eva; Clotet, Bonaventura; Marti, Ramón; Ballana, Ester; Esté, José A.

     

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    Pauls, Eduardo; Badia, Roger; Torres-Torronteras, Javier; Ruiz, Alba; Permanyer, Marc; Riveira-Muñoz, Eva; Clotet, Bonaventura; Marti, Ramón; Ballana, Ester; Esté, José A. AIDS. 2014 Jul 17

  • HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1

    Nuria Izquierdo-Useros, Maier Lorizate, Paul J. McLaren, Amalio Telenti, Hans-Georg Kraüsslich, Javier Martinez-Picado

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    Izquierdo-Useros N, Lorizate M, McLaren PJ, Telenti A, Kräusslich H-G, et al. (2014) HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1. PLoS Pathog 10(7): e1004146

  • Cell Cycle Control and HIV-1 Susceptibility Are Linked by CDK6-Dependent CDK2 Phosphorylation of SAMHD1 in Myeloid and Lymphoid Cells

    Eduardo Pauls, Alba Ruiz, Roger Badia, Marc Permanyer, Albert Gubern, Eva Riveira-Muñoz, Javier Torres-Torronteras, Mar Álvarez, Beatriz Mothe, Christian Brander, Manel Crespo‖, Luis Menéndez-Arias, Bonaventura Clotet, Oliver T. Keppler, Ramon Martí, Francesc Posas, Ester Ballana and José A. Esté

     

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    Eduardo Pauls et al. J Immunol. 2014 Jul 11. pii: 1400873

  • HCV-Induced Immune Responses Influence the Development of Operational Tolerance After Liver Transplantation in Humans

    Felix Bohne1,2,*, María-Carlota Londoño1,*, Carlos Benítez1, Rosa Miquel3, Marc Martínez-Llordella4, Carolina Russo5, Cecilia Ortiz6, Eliano Bonaccorsi-Riani4, Christian Brander7, Tanja Bauer5, Ulrike Protzer2, Elmar Jaeckel8, Richard Taubert8, Xavier Forns1, Miquel Navasa1, Marina Berenguer6, Antoni Rimola1, Juan-José Lozano9,† and Alberto Sánchez-Fueyo1,4,†‡

     

    1Liver Unit, Hospital Clinic Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), University of Barcelona, Barcelona 08036, Spain.

    2Institute of Virology, Technische Universität München–Helmholtz Zentrum München, Munich 81675, Germany.

    3Department of Pathology, Hospital Clinic Barcelona, IDIBAPS, University of Barcelona, Barcelona 08036, Spain.

    4Institute of Liver Studies, MRC Centre for Transplantation, King’s College London, London SE5 9RS, UK.

    5Clinical Cooperation Group Monitoring, Helmholtz Zentrum München, Munich 81675, Germany.

    6Liver Unit, Hospital La Fe Valencia, CIBERehd, University of Valencia, Valencia 46026, Spain.

    7Irsicaixa AIDS Research Institute, Institució Catalana de Recerca i Estudis Avançats, Barcelona 08916, Spain.

    8Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover 30625, Germany.

    9Bioinformatics Platform, CIBERehd, Barcelona 08036, Spain.

    F. Bohne et al. HCV-Induced Immune Responses Influence the Development of Operational Tolerance After Liver Transplantation in Humans. Sci. Transl. Med. 6, 242ra81 (2014)

  • SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors

    Ester Ballana, Roger Badia, Gerard Terradas, Javier Torres-Torronteras, Alba Ruiz, Eduardo Pauls, Eva Riveira-Muñoz, Bonaventura Clotet, Ramón Martí and José A. Esté

     

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    Ester Ballana, Roger Badia, Gerard Terradas, Javier Torres-Torronteras, Alba Ruiz, Eduardo Pauls, Eva Riveira-Muñoz, Bonaventura Clotet, Ramón Martí and José A. Esté. Antimicrob Agents Chemother. 2014 Aug;58(8):4804-4813